Article info.

ABSTRACT

Received 11 Jun 2020
Revised 10 Sep 2020

Accepted 30 Nov 2020

Resorcinol with its two hydroxyl groups was derivatized in laboratory to observe the anti-inflammatory potential in vitro. Subsequently, in silico docking analysis was done for observing the binding modes in cyclooxygenase enzyme to have idea about the subsequent possible developments. At the doses of 200 mg/mL and 400 mg/mL, the compounds showed the anti-inflammatory property. Among them, 1,3-phenylene bis(2-chloro-4-nitrobenzoate) also offered dose dependent 51% and 70% of inhibition of heat-induced hemolysis respectively. The scaffold thus poses as an interesting pharmacophore suitable for further development for managing the inflammatory disorders.

Keywords

Anti-inflammatory, docking, nitrobenzoic acid, resorcinol

Cited as: Mahmuda, R., Islam, S., Shoshi, N.S., Poly, K.A., Saha, P., Akhter, S., De, T.Q. and Bepary, S., 2020. In vitro anti-inflammatory resorcinol derivatives and their in silico analysis. Can Tho University Journal of Science. 12(3): 80-84.