Đăng nhập
Tìm kiếm nâng cao
Tên bài báo
Tác giả
Năm xuất bản
Tóm tắt
Lĩnh vực
Phân loại
Số tạp chí

Bản tin định kỳ
Báo cáo thường niên
Tạp chí khoa học ĐHCT
Tạp chí tiếng anh ĐHCT
Tạp chí trong nước
Tạp chí quốc tế
Kỷ yếu HN trong nước
Kỷ yếu HN quốc tế
Book chapter
Tạp chí quốc tế 2018
Số tạp chí 163(2018) Trang: 2085-2097
Tạp chí: Archives of Virology

Very virulent infectious bursal disease virus (vvIBDV) targets B lymphocytes in the bursa of Fabricius (BF), causing immunosuppression and increased mortality rates in young birds. There have been few studies on the host immune response following vvIBDV infection at different inoculum doses in chickens with different genetic backgrounds. In this study, we characterized the immune responses of specific-pathogen-free (SPF) chickens and Malaysian red jungle fowl following infection with vvIBDV strain UPM0081 at 103.8 and 106.8 times the 50% embryo infectious dose (EID50). The viral burden, histopathological changes, immune cell populations, and expression of immune-related genes were measured and compared between infected and uninfected bursa at specific intervals. The populations of KUL1+, CD3+CD4+ and CD3+CD8+ cells were significantly increased in both types of chickens at 3 dpi, and there was significant early depletion of IgM+ B cells at 1 dpi in the red jungle fowl. vvIBDV infection also induced differential expression of genes that are involved in Th1 and pro-inflammatory responses, with groups receiving the higher dose (106.8 EID50) showing earlier expression of IFNG, IL12B, IL15, IL6, CXCLi2, IL28B, and TLR3 at 1 dpi. Although both chicken types showed equal susceptibility to infection, the red jungle fowl were clinically healthier than the SPF chickens despite showing more depletion of IgM+ B cells and failure to induce IFNB activation. In conclusion, high-dose vvIBDV infection caused an intense early host immune response in the infected bursa, with depletion of IgM+ B cells, bursal lesions, and cytokine expression as a response to mitigate the severity of the infection.

Các bài báo khác
Số tạp chí 7(2018) Trang: 48-53
Tạp chí: The International Journal of Engineering and Science (IJES)
Số tạp chí 70(2018) Trang: 841-863
Tạp chí: Computational Optimization and Applications
Số tạp chí 7-26(2018) Trang:
Tạp chí: International Journal of Foreign Language Teaching and Research
Số tạp chí 4th(2018) Trang: 36-47
Tác giả: Nguyễn Văn Thu
Tạp chí: The 4th International Asian-Australasian Dairy Goat Conference 17-19 October, 2018, Tra Vinh Univ. Vietnam
Số tạp chí 0(2018) Trang:
Tạp chí: Discrete Optimization
Số tạp chí 7(2018) Trang: 473-477
Tạp chí: International Journal of Science and Research
Số tạp chí Volume 10 Issue 4(2018) Trang: 147-159
Tạp chí: International Journal of Innovations in Engineering and Technology (IJIET)
Số tạp chí Vol-4, Issue-10(2018) Trang: 1-8
Tạp chí: International Journal of Environmental & Agriculture Research (IJOEAR)
Số tạp chí 5(1)(2018) Trang: 196-203
Tạp chí: The Pharmaceutical and Chemical Journal
Số tạp chí Volume 7 Issue 11, November 2018(2018) Trang:
Tạp chí: International Journal of Science and Research (IJSR)
Số tạp chí 7(2018) Trang: 239-243
Tạp chí: International Journal of Science and Research

Vietnamese | English

Vui lòng chờ...