This experiment was conducted to evaluate the effects of dietary vitamin E supplementation in female rabbits on reproductive performance and economic efficiency, monitored across three consecutive litters using artificial insemination. The experiment was arranged in a completely randomized design with 32 crossbred doe rabbits (New Zealand White × local), aged 8-8.5 months, with an average body weight of 2.693 ±115 g, and they were divided into 4 treatments, each consisting of 8 replicates. The diet of all rabbits in the experiment was the same, contained 21% crude protein (CP) and 10.5 MJ/KgDM of metabolizable energy (ME). The experimental treatments were as follows: Treatment 1 served as the control, without vitamin E supplementation (E0), while the other treatments included dietary supplementation with vitamin E at levels of 40 mg/kg DM (E40), 80 mg/kg DM (E80), and 120 mg/kg DM (E120). Artificial insemination was used for all experimental rabbits. The experiment results showed that the E80 performed better than the others in terms of conception rate, mean weight at birth, milk yield of doe, mean weight at weaning (P>0.05), and produced the highest economic efficiency.