The effect of Vernonia cinerea extracts on cell viability and melanogenesis was investigated by using mouse B16 malanoma cell model. The results showed all extracts reduced the viability of B16 cell in dose-dependent manner and enhanced the melanogenesis in which ethanol extract a 200 μg/mL exhibited 2.5 folds increase in melanin content in comparision to untrested cell. DPPH and ABTS^+. correlated in both methods in which indicated antioxidant activities of the extracts. The antioxidant activity decreased in manner, the ethanol 70%, ethanol, water and ethanol 50% extract.