Orange-fleshed sweet potato (OFSP) noodles were created by replacing a portion of the wheat flour with OFSP flour in a formulation. This study was performed to identify the physical and chemical characteristics as well as sensorial attributes of noodles prepared from OFSP with some flours (wheat flour and semolina). The addition of xanthan gum and incubation time was examined. Instrumental analyses of noodles (cooking loss, volume increase, rehydration ratio, structure and microstructure) were carried out to assess the impact of experimental factors. The obtained results revealed that noodles made with more OFSP flour had a more yellow color than those with less OFSP flour. The mixture of OFSP and wheat flour in the formula F2 (the percent of OFSP 18.79% and wheat flour 28.18%) produced noodles with high quality and was the most favorable in appearance, taste, texture, and acceptability among the four formulas. Cooking weight and volume were increased from 164.89 to 174.12% and from 184.74 to 194.81%, respectively when semolina was added to the formula. The supplemental semolina 10.57%, xanthan gum of 2% and the incubation time 30 mins were obtained to enhance dough binding properties. The results suggest that OFSP flour could be replaced up to 40% wheat flour for noodles to improve the nutritional value (i.e. increased b-carotene) and might be acceptable to consumers with health food.