This study investigates hypoglycemic symptoms and physiological/ biochemical markers in dogs with parvovirus or distemper in Ho Chi Minh City. The survey of 10 cases of dogs with brown bloody diarrhea showed decreased red blood cell counts of 3.99 million/mm³ (8/10 samples), decreased and increased white blood cell counts (4/10 and 4/10, respectively), and eight cases had extremely elevated AST. The AST, ALT, urea, and creatinine indexes rose in dogs exhibiting neurological symptoms; in contrast, the quantity of red and white blood cells dropped. Findings from the blood physiological index study of dogs infected with the parvovirus reveal that aberrant white blood cell indices (increased or decreased) were present in 50% of blood samples. According to survey results, of the 20 cases that tested positive for parvovirus, 14 cases (70%) had an increased AST index, while 4/20 (20%) had an increased ALT. Thirty cases (58.8%) of reduced blood sugar levels were found in a survey of fifty-one dogs who tested positive for the parvovirus and Carré. Of these, six cases had a minor fall in the blood sugar index, and twenty-four cases had a significant decrease.