The study provides useful knowledge of growth and condition factor of Glossogobius aureus, a native commercial fish. Data analysis of 1073 individuals collected using bottom gill nets from June 2016 to May 2017 in the Mekong Delta showed that male and female weights at different sizes, seasons and study sites could be determined from a fish given length due to high coefficient values of the fish length and weight relationship (LWR). The goby showed a similar in growth parameter (b) between genders, seasons and study sites but not fish sizes. This goby was isometric growth since b obtained from LWRs closed to three. Although condition factor (K) showed sexual, intraspecific, seasonal, spatial and temporal changes, K was near the favourable environment of one, suggesting the goby adapted well to habitat. The results contributed essential data on fish biology being used for fish management.