Ben Tre province is located in coastal Mekong Delta and recognized as one of most potential province affected by climate change and saline intrusion. The present study conducted at three coastal districts of the province to assess appropriate farming systems in terms of economic return to each ecological zone including freshwater zone (saline controlled), brackish zone (salt-reshwater interface zone) and saline zone (saline un-controlled). Data on economic performance of different farming systems in the three sites and ecological zones were collected through conducting PRA exercise, interviewing 453 households and recording of 35 farmers carrying out trials. Results from analysis of economic return indicated that eexisting farming systems can generate relatively high income, and are promising farming systems in term of high economic return in saline affected areas in three districts. There are a significant different about farming systems and income level of households amongst ecological zones and farmers groups. Better-off farmers have the highest income while poor farmers have the lowest income. Tiger shrimp farming system and up-land crop can make highest profits. Diversified farming systems tested in three ecological zones produce high economic returns and those can offer to salinity intrusion adaptation and mitigation strategies.