The study was conducted to build a geographic information system (GIS) database for hazardous waste management in the Ninh Kiều district, Cần Thơ city to support managing a large database which is currently available in the hard-copy format. The data include location of facilities producing hazardous waste, quantity and composition of waste released over the period from 2010 to 2013. Such database were collected through field surveys combined with collecting secondary data from the Agency of Environmental Protection at the Can Tho city. Digitizing and structuring the collected database from different formats were done in order to standardise the available database in a GIS format. In addition, descriptive statistics and spatial analysis were applied to evaluate the hazardous waste released in the period as well as the spatial distribution of waste. The results showed that the number of waste sources and volume of hazardous waste released tend to increase in the period from 2010 to 2013. In addition, there were differences in terms of quantity waste as well as unevenly spatial distribution of the existing facilities. Thematic maps were created as a suitable base supporting hazardous waste management.