Biodiversity of the littoral macroinvertebrate communities was researched in 8 stations in An Giang, Dong Thap, Can Tho and Vinh Long. Results of study showed 125 species of 3 major phylum of macroinvertebrate: Mollusca, Arthropoda and Annelida. The results indicated that littoral macroinvertebrate communities were quite highly biodiversified (the Shanon –wiener index H’ =0.2 –3.1) and dense(1 –1251 ind./m 2)