The Mekong Delta is home to many different ethnic groups, mainly Kinh, Khmer, Hoa and Cham, etc. They have united in the process of building and protecting the Mekong Delta region. In the process of development, there has been a process of cultural communication of the residents in the Mekong Delta region. Since then, Khmer culture has undergone a transformation, with its own cultural characteristics, expressing the national cultural identity and common cultural characteristics, showing the harmony with the culture of the other ethnic groups in the Mekong Delta region.