An efficient five-step synthetic process towards benzimidazole-based hydroxamic acid derivatives was
successfully designed starting from 1-halo-2-nitrobenzenes and 2-substituted benzylamines. Based on
this procedure, eight thioether-linked N-benzyl benzimidazolyl hydroxamic acid derivatives (8a-h) were
successfully synthesized in good total yield (57-66%). The structures of these compounds were fully
determined based on spectroscopic data including HR-MS, FT-IR, 1H-NMR and 13C-NMR