The present study was conducted to determine the effect of dietary supplementation of Phyllanthus urinaria and Terminalia catappa extracts on enhancing growth, innate immunity, and disease resistance of whiteleg shrimp Penaeus vannamei. A commercially available feed diet was incorporated with a concentration of 1% P. urinaria and 1% T. catappa extracts (experimental treatments), and the feed without herbal extract was considered the control treatment. The results showed that the dietary supplementation of 1% P. urinaria extract increased the daily weight gain and specific growth rate of shrimp (pP. urinaria and 1% T. catappa extracts recorded a lower feed conversion ratio and had no effect on the survival rate of whiteleg shimp (p>0.05). The dietary supplementation of 1% P. urinaria and 1% T. catappa extracts significantly enhanced the shrimp non specific immune response after 4 weeks of herbal supplementation. The shrimp fed a diet containing 1% T. catappa extract showed significantly higher survival than those fed the control diet (pT. catappa extract.