This study was carried out to survey the composition and amount of domestic solid waste generated and management work in Cai Khe ward, Ninh Kieu district, Can Tho city. Households and staff in Cai Khe ward were interviewed to collect information on management assessment while waste collection tools were placed in the households to calculate generation rate and waste composition. The research results showed that the rate of domestic solid waste generation of the household and individual were 0.74 kg/household/day and 0.2 kg/person/day, respectively. Domestic solid waste in the study area has a a veriety of composition, of which organic waste accounted for the highest proportion (72.7%), plastic component accounted for 13.4%, and glass tookup 2.7%, hazardous waste occupied 1.4% and other components accounted for 3.6%. Currently, only 90% of domestic solid waste was properly collected. Odor and leachate remained the problems during waste collection and transportation. In overall, the management of domestic solid wastes in Cai Khe ward is relatively good. In order to ensure a clean and beautiful environment in the study area, the environmental management agency should continue to propagate to raise people's awareness of environmental protection, creating favorable conditions for sorting wastes at source for the improvement of solid waste collection, transportation, and treatment facilities.