The study aimed to evaluate the soil environmental characteristics of Vinh Long Province’s perennial crop-growing area using principal component analysis (PCA) and cluster analysis (CA). Soil environmental quality data were collected in eight districts of Vinh Long province for 27 physical and chemical parameters. CA and PCA analysis was used to group and identify critical parameters affecting perennial crops’ soil environment. The findings demonstrate low to moderate soil compaction porosity, buffering capacity, and structure for perennial crops. In addition, the soil has a low pH, electrical conductivity, total soluble salts, aluminum, and cation exchange capacity. Although rich in nutrients, the content of organic matter, available phosphorus, cations, and trace elements is only low to moderate. CA results showed three districts suitable for strongly developing perennial crops: Tra On, Mang Thit, and Vung Liem. The PCA results showed that except for density, the buffer capacity of the soil, and dissolved Al3+, the upcoming monitoring program must incorporate all remaining criteria. The study’s findings offer crucial information to help the management organization devise strategies for enhancing and sustainably expanding perennial crops in the province. It is necessary to further evaluate the soil’s environmental quality over time and soil depth and determine the frequency of monitoring in the study area.