This study was conducted to apply the GIS technology and algorithms to assess the land use fluctuation and the land demand forecasts for socio-economic development, the case study in Ca Mau town, Ca Mau province. The GIS method and Markov chains were main used in this study. In addition, the household interviews approaches with 100 questionnaires were conducted to collect the informations on agricultural production, the factors that changed the land use. The data were aggregated, analyzed and evaluated by descriptive statistics method. The results showed that the land use change in the period 2005 -2015 up to 74,99% of total area. The demand for land as forecasted by the Markov chain that the area of agricultural will reduce for conversion to residential, specialized land and aquaculture. This research has demonstrated the supporting of the GIS technology and Markov chain in the decision making, sustainable planning of land resources.