Over the past years, higher education in the Mekong Delta has played an important role inhuman resourcse training, scientific research, and technology transfer, promoting the regional socio-economic development. However, today, it has revealed limitation affecting the regional development. Within this article, the author has delved into analyzing the achievements and limitations of higher education, and then some solutions are proposed to develop higher education, meet the current needs for the regional economic development, whichare greatly meaningful in both theory and reality