Coronavirus disease 2019 (COVID-19) was found first in Wuhan (China), which was considered as an infectious disease caused by severe acute respiratory syndrome coronavirus 2. Hence, in order to prevent an increasing infectious disease risk, current management strategies against COVID-19 should strictly comply for stopping-up the spread of COVID-19 outbreak. There is a major challenge in the timely diagnosis (by kits, etc.) to prevent COVID-19 infection outbreak until proper drugs or vaccines for treating COVID-19 patients are introduced. Therefore, it is essential to demand personal protective manners for each person in against of COVID-19 infection. In this article, the symptoms of COVID-19 and the effect of handwashing in against of COVID-19 are mentioned, as well as its benefits in the COVID-19 infection prevention are understood more clearly.