Thanh Phu is a coastal district of Ben Tre province, located in the East of the Vietnamese Mekong Delta, between Ham Luong and Co Chien rivers and covering 25 km of coastline along the East Sea. Thanh Phu has great advantages for socio-economic development. However, the impact of climate change in recent years, especially saline intrusion has greatly affected the agricultural production in this district. According to a report of Ben Tre province in 2016, the salinity concentration reached the peak at 4‰ at the intrusion length of 45-65 km from the river. The saline concentration was about 1‰ at the intrusion length over 70 km. The measured salinity at Ham Luong river in Phu Khanh commune, Thanh Phu district was 6.9‰ at the intrusion length of 25 km from the river mouth. In early March 2019, the saline intrusion caused damage of 13,844 ha of rice areas in the WinterSpring season (over 90%), the total damaged area was about 503 ha. The total number of households affected due to lack of freshwater for daily life was 88,208 households with over 353,000 people over three coastal districts including Thanh Phu. As one of the coastal districts of Ben Tre province, Thanh Phu has been facing the serious impacts of saline intrusion. Therefore, the research aims to analyze the effect of salinity intrusion on agricultural land use at the household level in Thanh Phu district, Ben Tre province, Vietnam.