Managing English teaching activities for Grade 10 in high schools is one of the most important tasks and activities because it plays a decisive role in the success of teaching and the improvement of teaching quality for Grade 10 in high schools. This activity shows not only the results and quality of the students’ study but also the education management of managers and teaching activities of teachers in Ninh Kieu District, Can Tho City, Vietnam. The study was conducted at 4 high schools in Ninh Kieu District, Can Tho City, namely Phan Ngoc Hien High School, Chau Van Liem High School, An Khanh High School, and Nguyen Viet Hong High School. Participants in the survey by questionnaires were school managers (n = 4), English teachers (n = 17) and 10th Graders (n = 456). And the findings showed that to achieve the desired effect in the management of teaching activities of 10th Grade English at a high school in Ninh Kieu District, Can Tho City, the administrator or the school leader needs to have appropriate management measures and implement those measures in a synchronous and unified manner. Besides, through the use of measures, school leaders can recognize the positive aspects as well as the limitations of the situation. From there, management staff can continue to promote strengths and overcome existing weaknesses and limitations, and make adjustments in a timely manner. Some measures can be mentioned as follows: organizing activities to raise awareness about the importance of teaching 10th Grade English; organizing professional and professional training activities for 10th Grade English teachers; strengthening the management of the content and curriculum development of 10th Grade English subjects; directing the renewal of teaching methods and forms of organization of teaching activities in Grade 10 English; directing the renewal of forms and methods of studying English for 10th Grade students; directing the renewal of the form of examination and assessment of students' learning results in English 10; strengthening facilities and equipment to serve the teaching of 10th Grade English in high schools.