Objective: The goal of the study is to demonstrate the impact of work stress on the well-being and performance of doctors in the context of the Covid-19 epidemic.

Method: In this study, quota sampling based on the criteria such as gender, age, education background, working place is used to collect data. The survey areas are major cities in Vietnam, including Ho Chi Minh City, Da Nang City, and Can Tho City. After the data screening step, the study collects 252 observations. The study applies structural equation modeling to analyze the data.

Results: The result has shown factors constituting doctors’ occupational stress include work overload, pressure from superiors, time pressure, income pressure, working conditions, and workplace relationships. Stress at work negatively affects doctors' well-being and performance. Besides, the study has pointed out a positive relationship between perceived happiness and doctors’ performance.

Conclusions: Hospital administrators need to control the causes of work pressure to improve the feeling of happiness and performance. The causes include work overload, pressure from superiors, time pressure, income pressure, working conditions, and workplace relationships. In particular, work overload needs to be paid the most attention.