Tocopherol and γ-oryzanol compounds are phytochemicals with antioxidant activities and potential health benefits. Their contents and isomer ratios in rice bran vary among Mekong River Delta cultivars, suggesting that breeding for higher contents or a favorable ratio of these phytochemicals is feasible. Response surface methodology (RSM) was employed to optimize the process conditions for the direct solvent, microwave and ultrasonic-assisted extraction of these phytochemicals extract with methanol as the extraction solvent. The results showed that optimal conditions for extracting these phytochemicals extract as follows: methanol/rice bran ratio of 16 (weight/weight); extraction temperature of 51-55ºC and the extraction time of 9-10 minutes.