Mekong Delta Development Research Institute (MDI) – Can Tho University has cooperated with Southeast Asia Regional Initiatives for Community Empowerment (SEARICE) since 1996 to implement the projects on strengthening capacity for farmers and local institutions in participatory plant breeding and on-farm biodiversity conservation; The project conducted training FFS for farmers with on-farm practices and established “Seed clubs” for seed production and supply in the Mekong Delta. 20 years of implementation, the project trained 75,071 farmers and 541 local technicians; Farmers selected and released 328 new rice varieties for community use in which HD1 and NV1 varieties were certified at national level by MARD; 407 Seed club network produced and contributed more than 30% of total seed requirement in the Mekong Delta. Now farmers and local partners have experienced and empowered through their results and recommend local policies to support for farmer’s activity. Local support institutions are necessary to enhance farmer’s capacity for on-farm biodiversity conservation to climate change adaptation.