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Bài báo - Tạp chí
13 (2015) Trang: 2206–2215
Tạp chí: European Journal of Inorganic Chemistry

The hydrolytic activity of the ZrIV-substituted Keggin-type (Et2NH2)8[{α-PW11O39Zr-(μ-OH)(H2O)}2]·7H2O (1), Lindqvist-type (Me4N)2[W5O18Zr(H2O)3] (2), and Wells–Dawson-type Na14[Zr4(P2W16O59)23-O)2(OH)2(H2O)4]·57H2O (3) polyoxometalates (POMs) towards the peptide bonds in the oligopeptides triglycine, tetraglycine, glycylglycylhistidine, and glycylserylphenylalanine was investigated by kinetic methods and multinuclear NMR spectroscopy. 31P NMR and UV/Vis spectroscopy showed that 13 were stable under the conditions used to study peptide bond hydrolysis. The reactivity of 13 towards oligopeptides was compared on the basis of the amount of free glycine produced at a certain time increment. In the presence of 13, rate constants in the range 6.25 × 10–7 to 10.14 × 10–7 s–1 were obtained, whereas no hydrolysis was observed after one month in the absence of these POMs. The results showed that the Keggin-type complex 1 was the most active towards peptide bond hydrolysis in tri- and tetrapeptides. 1H and 13C NMR spectroscopy showed that triglycine, tetraglycine, and glycylserylphenylalanine interact with 1 and 2 preferentially through the amine nitrogen atom and the N-terminal amide oxygen atom to activate the peptide bond towards hydrolysis. The coordination of glycylglycylhistidine resulted in multiple complexes with 13 as a result of additional imidazole coordination to the ZrIV centers.

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Tải về
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Tạp chí: Young Belgium Magnetic Resonance Scientist 2013, 2nd-3rd December 2013, Blankenberge - Belgium
(2013) Trang:
Tạp chí: XIVth International Conference on Biological Inorganic Chemistry, Grenoble-France 22-27 July 2013
(2012) Trang:
Tạp chí: Chemistry conference for young scientists 2012 - ChemCYS2012, Blankenberge, Belgium 1-2 March 2012
(2012) Trang:
Tạp chí: Young Belgian Magnetic Resonance Scientist Symposium YBNMRS 2012 - Spa, Belgium 26-27 November 2012

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