This paper aims to analyze the factors affecting students' perceptions of the use of social network, specifically Facebook, for learning purposes. The study employed primary data collected from surveying 252 undergraduate students in 5 universities in Can Tho City, Vietnam. Descriptive statistics, Cronbach’s alpha, and regression have been used to analyse data. The results show 69.8% of students participated in the survey have used Facebook for learning purposes. Perceived Usefulness, Collaboration and Communication are three main determinants of the use of Facebook for academic purposes. Among those factor, collaboration seem to have the strongest impacts on the use of Facebook for academic purposes of students in Can Tho City, Vietnam.