Background and Objective: Natural compounds derived from plants are one of the promising therapies for various diseases, especially cancer. This study aimed to evaluate and compare the proficiency against oxidative stress and liver cancer cells of ten medicinal plants; to define the correlation between alkaloids, flavonoids and polyphenols, as well as to examine their cell protection ability. Materials and Methods: The samples were extracted with chloroform before conducting antioxidant activity determination by 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay, then evaluated anticancer activity via 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay using HepG2 cell lines. Result: The results indicated that E. sonchilofia had the highest amount of three bioactive compounds. M. pigra in ABTS assay gave the most efficient IC₅₀ value compared to the second large value of E. indica. Further investigation with MTT assay showed a significant difference in the anticancer capability of W. trilobata among others. The ethyl acetate fractioned extract showed a higher anticancer cell activity. The thin layer chromatography indicated the presence of terpenoids with the specific purple spot. Conclusion: Base on our results, the medicinal plant is a rich source of valuable bioactive compounds that can be potentially toxic to cancer cells.