The objectives of this study were analysis of the secondary metabolite products from extract of marine Streptomyces sp. strain ND7a which isolated from sponges at Ha Tien Sea, Kien Giang province, Vietnam. Six bioactive compounds were identified in the organic solvent hexan-aceton and aceton-methanol. The identification of bioactive chemical compounds is based on the peak area, retention time, molecular weight and molecular formular. GC-MS analysis of Streptomyces sp. strain ND7a revealed the existence of the 2-Pentanone, 4-hydroxy-4-methyl, Cyclohexasiloxane, dodecamethyl, Cycloheptasiloxane, tetradecamethyl, Oxime-, methoxy-phenyl, Hexanedioic acid, bis(2-ethylhexyl) ester and Diisooctyl phthalate.The Pharmaceutical and Chemical Journal