Rice farmers' perceptions and demand for pesticide use were analyzed using survey data in the Mekong Delta of Vietnam. The study showed although the majority of farmers could recognize the harmful effects of pesticides, they did not wear protective clothing suggested by WHO for pesticide safety use because they did not feel comfortable to use under local climatic conditions. Most of farmers declared that they asked for information or instructions related to pesticide use and pest prevention from retailers (72.5 percent) and over half of them (52.5 percent) sold their pesticide empty packages. The study also investigated that an increase in output price or farmers who thought an increasing tendency of insects and diseases had positive impacts on pesticides, while farmers who had knowledge on natural enemies or took part in short trainings or workshops applied less pesticides than others.