An experiment was carried out to determine the effect of catfish by-product meal (CB) base diet with inclusion of some herbal powder: Turmeric (T), ginger (G) or garlic (GA) in the diets on feed intake, growth performance and health status of local chickens in a confine house system. A total of 300 Noi chickens (female) at 5 weeks of age were randomly allocated into five dietary treatments, each with three replicates of 20 chicks/replicate (n = 60). Treatments were: (1) FM: Basal feed ingredients (B) + marine fish meal (control); (2) CM: B + CB; (3) CMT: CM + turmeric; (4) CMG: CM + ginger; (5) CMGA: CM + garlic at 3g/kg feed for all supplements. The feeding experiment was carried out for 11 weeks’ experiment (5-15 weeks age). The different parameters measured included: Feed intake, weight gain, feed conversion ratio, bacteria density in chicken feces, morbidity and mortality rate. Results showed that: Feed intake (ADFI) of the experimental birds in all groups was not significant different. Average daily gain (ADG) was found to be significantly (p in all supplemented treatments to compare with that in non-supplemented diets, in which E.coli density was lowest in chickens fed CMGA. So the lowest morbidity and mortality were in CMGA (13.3% and 6.7) to compare with FM (22.2 and 15.5%). It is concluded that there was an improvement in growth rate and feed conversion ratio, linked with a reduction in pathogenic bacteria (E.coli and Clostridium perfringens), and morbidity, mortality when chickens were supplemented with garlic, ginger and turmeric herbal powder. Key words: herbal powder, turmeric, ginger, garlic, local chicken, Tra catfish byproduct meal