Đăng nhập
 
Tìm kiếm nâng cao
 
Tên bài báo
Tác giả
Năm xuất bản
Tóm tắt
Lĩnh vực
Phân loại
Số tạp chí
 

Bản tin định kỳ
Báo cáo thường niên
Tạp chí khoa học ĐHCT
Tạp chí tiếng anh ĐHCT
Tạp chí trong nước
Tạp chí quốc tế
Kỷ yếu HN trong nước
Kỷ yếu HN quốc tế
Book chapter
Tạp chí quốc tế 2022
Số tạp chí 76(2022) Trang: 4561–4570
Tạp chí: Chemical Papers

This study developed and characterized the chitosan-functionalized Fe3O4@SiO2 nanoparticles (Fe3O4@SiO2@CS NP) as a drug delivery system. Fe3O4 NP were first synthesized by co-precipitation method, followed by coating with SiO2, and functionalized with chitosan via glutaraldehyde crosslinking bridges. The newly synthesized Fe3O4@SiO2@CS NP possessed an octagonal shape with a diameter of ~ 20 nm. In the FT-IR spectrum, the Fe3O4@SiO2@CS NP demonstrated the appearances of C–O, N–H, and C–H peaks, indicating the presence of chitosan in their structures. The Fe3O4@SiO2@CS NP could preserve the Fe3O4 magnetic property with a magnetization value of 52.43 emu/g, a magnetization remanence of almost 0 emu/g, and minimal residual coercivity. Utilizing curcumin as a drug model, the Fe3O4@SiO2@CS NP could adsorb the drug rapidly, to more than 71% within 20 min, with an adsorption capacity of 6.54 mg/g and an adsorption energy of 0.2029 kJ/mol (following the Dubinin–Radushkevich model). The curcumin adsorption process was in good agreement with the pseudo-second-order kinetics (R2 = 0.9975). Interestingly, in the simulated body fluid, the curcumin-loaded Fe3O4@SiO2@CS NP could retain the curcumin release, with no detectable drug release, in the first hour, followed by a burst release within the next hour. This confirms the contribution of CS in the system. Conclusively, the Fe3O4@SiO2@CS NP could be further developed to potentially become a controlled-release drug delivery system.

Các bài báo khác
Số tạp chí 31(2022) Trang: 1031-1050
Tạp chí: Statistical Methods in Medical Research
Số tạp chí 13(2022) Trang: 557-562
Tạp chí: International Journal of Advanced Computer Science and Applications
Số tạp chí 13(2022) Trang: 509-514
Tạp chí: International Journal of Advanced Computer Science and Applications
Số tạp chí 71(2022) Trang: 1021-1053
Tạp chí: Optimization
Số tạp chí 55(2022) Trang:
Tạp chí: Journal of Physics D: Applied Physics


Vietnamese | English






 
 
Vui lòng chờ...