Đăng nhập
Tìm kiếm nâng cao
Tên bài báo
Tác giả
Năm xuất bản
Tóm tắt
Lĩnh vực
Phân loại
Số tạp chí

Bản tin định kỳ
Báo cáo thường niên
Tạp chí khoa học ĐHCT
Tạp chí tiếng anh ĐHCT
Tạp chí trong nước
Tạp chí quốc tế
Kỷ yếu HN trong nước
Kỷ yếu HN quốc tế
Book chapter
Bài báo - Tạp chí
5 (2021) Trang: 559-563
Tạp chí: Tropical Journal of Natural Product Research

Elephantopus mollis (EM) is a wild species and is commonly used in folk medicine as remedy for various ailments. Some uses of this plant has been documented in the scientific literature. However, studies on the medicinal properties of this specie remain rarely published and the specie has not been recorded in the Vietnamese pharmacopeia. The present study therefore assessed the acute toxicity and liver-protective effects of Elephantopus mollis (EM). The acute toxicity of the aqueous extract of EM in mice was assessed following the method stipulated by the Organization for Economic Cooperation and Development (OECD), while the hepatoprotective effect was assessed following previously reported method. Whole plant extract of EM was not toxic to the tested mice (at a dose of 9,000 mg/kg) and showed good liver protection. The plant extract had the ability to reduce the degradation of liver cells by reducing the amount of liver enzymes. At a dose of 400 mg/kg EM, the reduction efficiency of AST and ALT in tested mice were 71.43 ± 11.36% and 63.82 ± 19.43%, respectively, when compared with the negative control group after 2 weeks of treatment. Mice liver morphology and histopathology treated with EM extract showed a decent improvement. The liver cells size of mice treated with EM extract decreased significantly (28.02 ± 6.33 µm) compared to the mice in the negative control group (34.82 ± 6.36 µm). The results suggest the potential effect of this extract as a hepatoprotective agent towards liver damage without any oral acute toxicity effect.


Các bài báo khác
Tập 55, Số CĐ Khoa học Giáo dục (2019) Trang: 105-114
Tải về
Số 16b (2010) Trang: 221-229
Tải về
Tập 55, Số 1 (2019) Trang: 62-68
Tải về
Số 36 (2015) Trang: 88-97
Tải về
Vol. 12, No 2 (2020) Trang: 9-14
Tải về
(2016) Trang: 15-24
Tạp chí: Hội Nghị Khoa học Khoa Sư phạm - Trường Đại học Cần Thơ - 2016

Vietnamese | English

Vui lòng chờ...