This study investigates the current status of pesticides use and management in paddy rice and durian Ri6 farming in Phong Dien district, Can Tho city, Vietnam by interviewing 60 farmers directly in this area. The results showed that the farmers often applied various types of pesticides belonging to toxicity categories II, III and IV according to World Health Organization (WHO) classification with 95 active ingredients. The paddy rice and durian Ri6 farming used 54 and 41 active ingredients, respectively. Among the active ingredients used, the Carbosulfan, Trichlorfon, Glyphosate, Paraquat, 2.4D, Acephate were banned from use. The frequency of spraying pesticides in durian farming model was 8.8 times higher than that of the paddy rice. Pesticide bottles and packages were often improperly handled by burning, burying, throwing in the fields, mixing with domestic waste or selling to vendors. Although the knowledge of the farmers is relatively good, the environmental and their health impacts were often neglected or considered unimportant. This leads to urgent need to raise awareness of the farmers in using and managing pesticides and its wastes to ensure sustainable agriculture development.