The main purpose of this study was to determine human and environmental threats from agro-input materials used in mango farming. The study employed the Environmental Quotient Impact model to measure agrochemical influences on farm-workers, consumers, and the environment through 230 sampling observations in the non-cooperative and cooperative groups in southern Vietnam. The findings show that the cooperative farmer group applies synthetic fertilizer in HoaLoc-mango production more efficiently than the non-cooperative farmer group in seasons, especially nitrogen fertilizer usage, the main source of nitrous oxide emissions, which causes environmental pollution. Additionally, farmer, consumer, and environment EIQ of the cooperative farmer group is better than that of the non-cooperative farmer group. In particular, the environment is the most vulnerable to pesticide overuse. Agro-input material usage was the highest in the first season, followed by the second season, and lowest in the third season. Therefore, agricultural policies need to enhance the progression of collective economics as a good opportunity to control chemical agro-input usage more effectively, raise producers^, environmental awareness, and reduce negative impacts on the health of farm-workers and consumers.