From July 2017 to March 2018, a total of 358 retail vegetables were collected to clarify the contamination of Salmonella in the Mekong Delta, Vietnam. Salmonella was isolated from 58 (16.2%) of 358 samples. The isolation rate of Salmonella from retail vegetables in the rainy season was significantly higher than that in the dry season, 20.9% and 7.3% respectively. Among of Salmonella isolates, Salmonella Weltevreden was the most predominant serovar (29.5%) identified from retail vegetable in all of the wet markets, followed by S. Derby (8.2%), S. Lexington (3.3%), S. Worthington (3.3%). All S. Weltevreden isolates (100%) were susceptible to 9 antibiotics examined (ABPC, OTC, CP, NA, CEZ, SM, KM, GM, and OFLX). As peoples in Southeast Asian countries have a habit to eat raw vegetables, they could be infected with Salmonella via consumption of Salmonella-contaminated vegetables. Thus, retail vegetables were considered as the important vehicle of Salmonella transmission to humans in the Mekong Delta.