Đăng nhập
 
Tìm kiếm nâng cao
 
Tên bài báo
Tác giả
Năm xuất bản
Tóm tắt
Lĩnh vực
Phân loại
Số tạp chí
 

Bản tin định kỳ
Báo cáo thường niên
Tạp chí khoa học ĐHCT
Tạp chí tiếng anh ĐHCT
Tạp chí trong nước
Tạp chí quốc tế
Kỷ yếu HN trong nước
Kỷ yếu HN quốc tế
Book chapter
Kỷ yếu hội nghị quốc tế 2013
Số tạp chí (2013) Trang:
Tạp chí: XIVth International Conference on Biological Inorganic Chemistry, Grenoble-France 22-27 July 2013
Liên kết:

Selective cleavage of peptides and proteins is one of the most important procedures in analytical biochemistry. However, the extreme inertness of the amide bond with a half-life estimated to be up to 600 years at physiological pH and temperature makes this task highly challenging. Several proteolytic enzymes are available, but they are usually not regioselective and cleave proteins in short fragments which are difficult to identify. The few existing synthetic reagents require harsh conditions and even when applied in great excess over the substrate, they tend to cleave proteins with partial selectivity and low yields. In the search for new artificial peptidases, metal-substituted polyoxometalates (POMs) have been intensively investigated in our research group for the hydrolysis of peptide bonds in peptides.[1] In this study, Zr(IV) was incorporated into monolacunary Keggin anions [PW11O39]7- to form a dimeric 2:2 Zr(IV)-substituted Keggin type POM, (Et2NH2)8[{?-PW11O39Zr(à-OH)(H2O)}2]?7H2O  (1). The stability of the POM is highly dependent on pH and its concentration, and can be monitored by 31P NMR spectroscopy. Various Gly-X and X-Gly dipeptides were proven to be effectively hydrolyzed by 1 and their hydrolysis was highly dependent on the nature of the side chain. The molecular mechanism of the peptide bond cleavage was elucidated based on combination of detailed kinetic experiments and multinuclear 1H, 13C and 31P NMR spectroscopy.

Các bài báo khác
Số tạp chí (2013) Trang:
Tác giả: Võ Văn Chương
Tạp chí: La motivation dans l'apprentissage et l'enseignement du FLE - Centre Regional Francophone pour l'EUrope Centrale et Oriental (CREFECO), Sofia, 23-25/10/2013
Số tạp chí (2013) Trang: 93
Tạp chí: The 10th Annual conference of the Asian reproductive Biotechnology society
Số tạp chí Số 2(2013) Trang: Article No.: 2
Tạp chí: The 2nd International Workshop on Cloud Intelligence (Cloud-I 2013)
Số tạp chí (2013) Trang: 2291
Tạp chí: European Geosciences Union General Assembly 2013, Vienna | Austria | 07 ? 12 April 2013
Số tạp chí (2013) Trang: Track E in Programme, ISSN number: 2295 - 1687
Tạp chí: 10th Worshop on Corporate Governance, Brussels, October 10-11, 2013
Số tạp chí 2(2013) Trang: 530-538
Tác giả: Phạm Xuân Minh
Tạp chí: 2nd Applied International Business Conference 7-8/12/2013, Malaysia
Số tạp chí 15(2013) Trang: 22-28
Tạp chí: Space, Time and Ambient Intelligence 2013 (STAMI 2013), Washington USA. July 14?18, 2013
Số tạp chí (2013) Trang: 168-173
Tạp chí: The 5th International Conference on Fermentation Technology for Value Added Agricultural Products
Số tạp chí (2013) Trang: 386-392
Tạp chí: The 5th International Conference on Fermentation Technology for Value Added Agricultural Products
Số tạp chí 1(2013) Trang: 1
Tạp chí: The Vietnamese seafood sector A value chain analysis
Số tạp chí 1(2013) Trang: 67
Tạp chí: Land Tenure Journal
Số tạp chí 1(2013) Trang: 1
Tác giả: Võ Văn Dứt
Tạp chí: The proceedings of the SOM PhD Annual Conference 2013
Số tạp chí 1(2013) Trang: 1
Tạp chí: International YOUNG SCIENTISTS CONFERENCE on thIntegrated Research on Disaster Risk, Future Earth and Sustainability
Số tạp chí 1(2013) Trang: 1
Tác giả: Trần Văn Tỷ
Tạp chí: International YOUNG SCIENTISTS CONFERENCE on thIntegrated Research on Disaster Risk, Future Earth and Sustainability
Số tạp chí 1(2013) Trang: 108
Tạp chí: THE 2013 INTERNATIONAL SYMPOSIUM ON ELECTRICAL AND ELECTRONICS ENGINEERING
Số tạp chí 1(2013) Trang: 28
Tạp chí: The 2013 International Workshop on Excellent Engineering Education
Số tạp chí 1(2013) Trang: 1
Tạp chí: Economic Impact of Water Pollution on Rice Production in Vietnam
Số tạp chí 3(2013) Trang: 61
Tạp chí: International perspectives on water quanlity management and pollutant control


Vietnamese | English






 
 
Vui lòng chờ...