This paper presents an assessment of the current state of the air quality affected by industrial, urban and transportation activities in Long Xuyen city, An Giang province in the period 2016-2019. Air quality monitoring data includes temperature, noise, total suspended dust (TSP), nitrite oxide (NO₂), sulfur dioxide (SO₂), carbon monoxide (CO), ozone (O₃), ammonia gas (NH₃) and hydrogen sulfur gas (H₂S) were provided by the Department of Natural Resources and Environment of An Giang province. The results showed that the quality of the air environment in industrial zones, urban areas and transport sites were within the permitted standards of Vietnam. However, the indicators of TSP, NO₂, CO, SO₂ tended to increase if it is not well controlled, which can consequently affect the environment and human health. The environmental managers need to strengthen monitoring of air environment quality so that there are timely solutions to overcome pollution problems to ensure public health. This study recommends that the relevant agency should measure acetaldehydes, and volatile organic carbons since these gases are toxic and regularly emitted.