As on December 02, 2015, the U.S. Department of Agricultural issued the “Final Rule on Mandatory Inspection of Fish of the Oder Siluriformes and Products Derived from such Fish” (hereafter 80 FR 75589). Accordingly, the 80 FR 75589 regulates that the inspection program on all fish of the order Siluriformes will be transferred from the FDA to the USDA by March 01, 2016. Besides, the inspection system of poultry is being applied to catfish. This rule is criticized to create more barriers for trading of catfish when such products are exported to the U.S market. By analysing the U.S regulations on catfish inspection program and the Sanitary and Phytosanitary Agreement (SPS Agreement), this paper will illustrate whether or not the U.S SPS measures on catfish is consistent with the WTO laws