This study investigated the effects of heat-killed Lactobacillus plantarum L-137 (HK L-137) on the growth, survival, and immune response of snakehead (Channa striata) cultured in practical field conditions with Hapa nets. The fish (13.7±4.73 g fish-1 ) were fed diets supplemented with 0 (control), 2, and 4 mg of HK L-137 kg-1 of feed. After feeding for 215 days, all fish were harvested. The results showed that HK L-137 supplemented diets improved the growth, protein efficiency ratio, feed conversion ratio, and survival rate of fish. HK L-137 supplemented diets also significantly increased the white blood cell count and lysozyme activity, but did not affect the red blood cell count. Hence, overall, dietary supplementation with HK L-137 enhance survival, growth and immune response of snakehead cultured under typical farming conditions