This study was aimed to investigate the effects of salinity on the reproductive physiology of striped snakehead Channa striata. Fish (the initial weight of 401±15 g fish-1 ) were cultured in three salinities including 0 (control), 3, and 6‰ in triplicates. The density was 30 fish per 1,000 L tank. After 4 months, the fish body mass of the control treatment was the highest (712±139 g fish-1 ). In the 6‰ treatment, the hematological parameters (hemoglobin concentration, hematocrit, and white blood cells) were significantly increased if compared to those of the control treatment, but there were insignificant differences in these hematological parameters between 3 and 6‰ treatments excepting hematocrit values. Plasma osmolality and chloride ion concentrations in the 6‰ treatment increased to 301±5.5 mOsmol kg-1 and 104±3.86 mM, respectively. The results also showed that the highest gonadosomatic index (GSI) of the females (5.8±2.62%) was found in the 3‰ treatment while the lowest (3.85± 1.95%) was recorded in the control treatment. The vitellogenin concentration was the highest in the 6‰ treatment, whereas the absolute fecundity and the relative fecundity were the highest at the 3‰ treatment. It proves that the striped snakehead matured in 0-6‰ water