This research is aimed at analyzing relevant economic theories and approaches on e-commerce to analyze the current situation to improve the effectiveness of e-commerce applications in developing countries. This research employed direct survey data from 164 households in the Mekong River Delta of Vietnam as a case study. The methodologies included descriptive statistics, 5 - point Likert scale, and a Logit model for analyzing households' perception and determinants of e-commerce adaptation. Research results reveal that households are willing to apply e-commerce, especially through several sustainable forms such as linkages with enterprises and apply advanced production techniques. In the case of developing countries where the government is facing financial and resource constraints, in order to solve this issue, the involvement of the community and private organizations including enterprises and cooperatives in the value chain of agricultural products to guide and support people in agriculture digital transformation is essential. The local government can then perform well as an observer or controller to ensure the quality, rights, and obligations of the stakeholders involved.