This experiment aimed to evaluate the effects of high saline water on physiological responses, nutrient digestibility and milk yield in lactating crossbred goats. Ten crossbred dairy goats were selected and divided into two groups, five animals each. Animals received either control (fresh water, DSW0.0) or high saline water (1.5% diluted seawater, DSW1.5). The results showed that rectal temperature (RT) and respiration rate (RR) from DSW1.5 were higher than those from DSW0.0 at 13:00 and 15:00 h. Dry matter intake, milk yield and body weight did not differ between groups. Dairy goats in DSW1.5 were lower water intake and urine volume, whereas plasma ADH concentration increased. Therefore, water balance was lower from DSW1.5 over 24 h. The results from present study indicated that dairy goats drank with 1.5% saline water which decreased thermoregulation’s capacity via higher RT and RR.