Miliusa velutina leaf contains a promising source of bioactive compounds since it has been traditionally used for the treatment of various diseases. The present study aimed at evaluating the effect of different solvents on phytochemical constituents, antioxidant and in vitro anti-inflammatory activities of Miliusa velutina leaves extracts. Aqueous solvent was identified as the most effective one for the extraction, resulting as the highest content of polyphenol (13.85±0.13 mg GAE/g extract) and flavonoid (267.34±4.93 mg QE/g extract). In addition, the study was conducted to evaluate the antioxidant and anti-inflammatory activities of Miliusa velutina leaves extracts. The antioxidant activity was determined using nitric oxide radical inhibition assay. In vitro anti-inflammatory activity was evaluated using albumin denaturation method. The results showed that the aqueous extract exhibited high capacity of antioxidant (EC₅₀ value of 157.08±2.90 μg/mL) and in vitro anti-inflammatory activity (i.e., albumin denaturation: IC₅₀=21.13±0.95 μg/mL). The antioxidant activity of the aqueous extract was found to be 4.63-fold higher than vitamin C, and the anti-inflammatory activity of Miliusa velutina extracts was comparable to diclofenac and prednisolon. Based on the obtained results, it can be concluded that Miliusa velutina leaves extracts displayed anti-inflammatory and antioxidant activity.