A study was conducted at the Experimental farm in Long Hoa commune, Binh Thuy district, Can Tho city to evaluate the effects of different replacement levels of Paederia tomentosa (PT) for Para grass in diets on nutrient utilization, growth performance, apparent nutrient digestibility and economic returns of growing crossbred rabbits. The feeding trial was a completely randomized design with 5 treatments and three replications. The treatments were 5 levels of 0, 25, 50, 75 and 100% Paederia tomentosa replacing Para grass (correspondings to the RM0, RM25, RM50, RM75 and RM100 treatments). There were 4 growing crossbred rabbits at 8 weeks of age (sexual balance) per experimental unit and the experimental time lasted in 12 weeks. The nutrient digestibility trial was done on 12 week- old crossbred rabbits in 7days to evaluate apparent nutrient digestibility and nitrogen retention. The results showed that PG intakes gradually decreased with increasing levels of PT in the diets, while paederia tomentosa intakes increased.